Miscarriage Research and Prevention.

Preventing pregnancy loss starts with knowledge

For IndividualsFor Clinicians
Children playing with bubbles, revealed through clusters of circles
~30%
of pregnancies end in miscarriage when you count from four weeks
~1 in 20
women have recurrent pregnancy loss: two or more miscarriages
1 in 3
women who miscarry meet the criteria for post-traumatic stress disorder (PTSD)
More than 1,000,000 miscarriages per year
are treated in the U.S., though the true number of losses is higher as many are never treated at all
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Our thesis

We believe we can prevent 1 in 7 miscarriages with simple, affordable preconception testing and treatment of common health conditions.With further research, we think that could reach 1 in 5.

Live Birth67.5%of PregnanciesMiscarriage30%of PregnanciesChromosomally Abnormal70% of MiscarriagesStillbirth0.5% of PregnanciesEctopic2% of PregnanciesChromosomally Normal30% of MiscarriagesMaternal HealthPaternal HealthParental LifestyleFetal GeneticsOtherUnknownPreventable WithFurther ResearchPreventable NowAt Least15%of MiscarriagesCould Be Live Births≈240,000 FewerMiscarriages Per Year
Where these shares come fromThis is a modelled distribution of all pregnancies counted from a positive hCG test at about four weeks, not a single measured cohort, and not limited to clinically recognised pregnancies. On that denominator roughly 3 in 10 end in loss; on the narrower clinically recognised denominator the pooled figure is 15.3%. Stillbirth and ectopic shares come from national surveillance.31% post-implantation loss: Wilcox et al., NEJM, 1988 ↗15.3% of recognised pregnancies: Quenby et al., The Lancet, 2021 ↗67% of miscarriages chromosomally abnormal: Cells, 2024 ↗Stillbirth 5.45 per 1,000: CDC fetal mortality, 2022 ↗Ectopic ~2% of pregnancies: ACOG Practice Bulletin 193 ↗
Chromosomally normal: ~30%The other ~70% of miscarriages carry chromosomal abnormalities, random errors that arise at conception and largely can’t be prevented.Chromosomal abnormalities in 7,118 miscarriages (67%): Cells, 2024 ↗Miscarriage epidemiology: Quenby et al., The Lancet, 2021 ↗
What sits behind a chromosomally normal lossSome of these we can already screen for and treat: iron-deficiency anemia, thyroid regulation, diabetes. Others are real but hard to address with current care, and chromosomally normal does not mean genetically normal: some losses carry single-gene variants a karyotype cannot see. In many cases no likely cause is ever identified. The preventable share below is drawn from across this list, not from any one line of it.Iron-deficiency treatment & pregnancy loss: cohort, 2025 ↗ATA guidelines: thyroid disease in pregnancy, 2026 ↗ADA: management of diabetes in pregnancy, 2026 ↗Variants in 25% of unexplained euploid loss: medRxiv, 2025 (preprint) ↗Diminished ovarian reserve & miscarriage: meta-analysis, 2021 ↗
Preventable nowConditions we can already screen for and treat before conception. The evidence is not equally strong for each. The strongest is for correcting iron deficiency and controlling diabetes; for bacterial vaginosis the association is contested and no trial has tested treating it before conception.Iron infusion, miscarriage OR 0.32: Finnish cohort, AOGS, 2025 (observational) ↗Poor glycaemic control, loss RR 3.0: Greene et al., Teratology, 1989 ↗Untreated hypothyroidism raises miscarriage risk: ATA guideline, 2026 ↗Bacterial vaginosis, early loss RR 1.68: Haahr et al., BJOG, 2019 (very low certainty) ↗Progesterone rescue with bleeding + prior loss: PRISM, AJOG, 2020 ↗
Preventable with further researchMechanisms under active investigation. Neither has been shown to reduce miscarriage. The metformin work measures pregnancy sickness, and the sitagliptin trial measured endometrial stem cells, not pregnancy outcome. That gap is what this band stands for, and why it fades.Metformin, GDF15 and pregnancy sickness: AJOG, 2025 (self-reported survey) ↗Sitagliptin raises endometrial stem cells: EBioMedicine, 2020 (n=38 feasibility) ↗
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