Enrolling now, and what we are watching

Research and clinical trials.

Studies moving the field forward: and ways to take part in them.

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Interested in contributing to research? The Hope Project studies the causes of pregnancy loss: anyone with one or more losses is eligible to participate.

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Browse the trials listed here: those marked Recruiting are enrolling participants now. Each links to its eligibility details and information on how to apply to join it.

Ongoing & Recruiting Trials

Studies we think are worth knowing about, taken from ClinicalTrials.gov. We are not running any of them and have no part in who they enrol; every row links to the official record. Checked 22 August 2026.

APPLE: aspirin before seven weeksmiscarriage preventionvery early lossaspirinpreeclampsiaTests whether starting 162 mg of aspirin before seven weeks of pregnancy prevents more losses and preeclampsia than the standard 81 mg started at twelve weeks, in women with at least one risk factor.Recruiting · PhiladelphiaNCT06408181 ↗Genomic predictors of recurrent pregnancy lossrecurrent lossgeneticsobservationalSequences the whole genome of couples and of the pregnancy tissue after a loss, to find genetic causes in people whose recurrent losses are otherwise unexplained. Focused on losses that were chromosomally normal.Recruiting · Nine sites, including Yale, Johns Hopkins, Columbia and NorthwesternNCT05444283 ↗IVIDA2: intravenous versus oral ironanemiasupplementsCompares a single iron infusion against standard iron tablets for iron-deficiency anemia in pregnancy, measuring anemia at delivery, transfusion, preterm birth and the child's later development.Recruiting · Eight sites, from Rhode Island to UtahNCT05462704 ↗Walk With Me: grief and post-traumatic stress after lossmental healthmanagement of lossTests a web-based grief programme, with and without a peer guide, against usual referrals, for post-traumatic stress and suicidal thinking after miscarriage, stillbirth or infant death.Recruiting · Remote, anywhere in the US; English or Spanish, age 15 and overNCT07011940 ↗ASPIRIN: which aspirin dose prevents preeclampsiapreeclampsiaaspirinpreterm birthCompares 162 mg against 81 mg of daily aspirin for preventing high blood pressure disorders of pregnancy in people at raised risk. At 10,742 participants it is the largest trial on this list.Recruiting · Sixteen sites nationwideNCT06468202 ↗DECIDE: metformin or insulin for gestational diabetesgestational diabetesCompares metformin tablets against injected insulin as the first treatment for gestational diabetes, measuring the effect on the baby's growth and on the mother's experience of treatment.Recruiting · Twenty-four sites nationwideNCT06445946 ↗Aspirin dose for preventing repeat preterm birthpreterm birthaspirinTests whether 162 mg of aspirin prevents more repeat preterm births than 81 mg, in people who have already had a preterm delivery.Recruiting · Fourteen sites nationwideNCT06980025 ↗Progesterone to prevent preeclampsiapreeclampsiasupplementsTests whether progesterone supplementation lowers the risk of preeclampsia and other high blood pressure disorders of pregnancy.Recruiting · Charleston, South CarolinaNCT07448597 ↗G-CSF after a chromosomally normal embryo failsrecurrent lossvery early lossmiscarriage preventionTests a growth factor in women who miscarry repeatedly after transfer of an embryo already screened as chromosomally normal; the group whose losses cannot be explained by chromosomes.Recruiting · United Arab EmiratesNot enrolling in the USNCT07724405 ↗LIGHT: levothyroxine for borderline thyroid functionrecurrent lossmiscarriage preventionTests whether treating mildly underactive thyroid in early pregnancy prevents further losses in women with recurrent miscarriage; the question current guidelines decline to answer for lack of evidence.Ongoing · ChinaNot enrolling in the USNCT06999278 ↗Hydroxychloroquine for thyroid-antibody-positive recurrent lossrecurrent lossmiscarriage preventionTests hydroxychloroquine added to levothyroxine in women who have normal thyroid hormone levels but positive thyroid antibodies and unexplained recurrent loss.Recruiting · ChinaNot enrolling in the USNCT06652113 ↗

Registry titles are written for regulators, so the summaries here are ours, written to be readable. They are not a substitute for the official record, which is where the eligibility criteria, contacts and any results live. Listing a trial is not a recommendation to join it; that is a decision for you and your clinician.

Finished: results not yet published

Trials that have completed enrolment but have not reported. We list them because the answers are coming and it is worth knowing what is on the way.

PREMI: prednisolone for unexplained recurrent miscarriagerecurrent lossmiscarriage prevention490 women with unexplained recurrent miscarriage, randomised to prednisolone or placebo in early pregnancy. A direct test of whether damping the immune response prevents loss.The largest randomised test of an immune treatment for unexplained recurrent loss. Finished last month, so a result is not due yet, but this is the one to watch.Enrolment completed July 2026NCT05725512 ↗CHOP-IT: progesterone for threatened miscarriagemiscarriage prevention1,656 women across 22 sites with bleeding in early pregnancy, randomised to oral progesterone, a herbal preparation, both, or neither.One of the largest threatened-miscarriage trials ever run. The progesterone comparison is informative on its own, whatever the herbal arm shows.Enrolment completed October 2025NCT02633878 ↗Medication versus waiting for first-trimester lossmanagement of loss183 women across 15 US sites, comparing a drug regimen against expectant management for a miscarriage that has already been diagnosed.Bears on what people are offered at the point of diagnosis; the decision almost everyone with a miscarriage actually faces.Enrolment completed May 2025NCT06121063 ↗A brief cognitive task to prevent post-traumatic stressmental healthmanagement of loss168 women randomised shortly after an early pregnancy loss or ectopic pregnancy to a short cognitive task or a placebo activity, to see whether intrusive memories could be reduced.Enrolment finished over two years ago. Given that around one in three women meet the criteria for PTSD after a loss, a cheap preventive intervention would matter; we are looking for the publication.Enrolment completed March 2024NCT05039853 ↗Conversational AI for periconception caremanagement of loss350 participants offered an automated texting service to improve access to care around early pregnancy and early pregnancy loss.A test of whether the gap between a loss and the next appointment can be filled without adding clinic capacity.Enrolment completed September 2025NCT06618144 ↗